Typical features of liver Histology in autoimmune hepatitis

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Nalerdon Chalermsuksant, M.D.
Napat Angkathunyakul, M.D.
Pongphob Intaraprasong, M.D.


Autoimmune hepatitis, interface hepatitis, lymphoplasmacytic infiltration, emperipolesis, hepatic rosettes


Autoimmune hepatitis is a chronic progressive liver disease which may present as acute hepatitis, chronic hepatitis or even cirrhosis. We report a case of 67-year-old female with diabetic mellitus and hyperlipidemia present with progressive fatigue for one year. Her liver function tests showed hepatocellular injury pattern, elevated serum IgG level and positive ANA 1:320 in homogeneous pattern. Her abdominal ultrasound revealed normal liver parenchyma and no bile duct dilatation. The liver biopsy showed interface hepatitis, lymphoplasmacytic infiltration, bridging necrosis, emperipolesis and hepatic rosettes. The diagnosis autoimmune hepatitis was made according to The Simplified Diagnosis Criteria and The Revised Original Scoring System of the International Autoimmune Hepatitis Group. Her clinical and laboratory were improved after received prednisolone and azathioprine.


Figure 1  พยาธิสภาพของชิ้นเนื้อตับย้อมด้วย hematoxylin และ eosin (H&E) 

  • รูป A และ B: Interface hepatitis (ลูกศรแดง), Cluster of plasma cells infiltration (หัวลูกศรดำ)

  • รูป C: Hepatic rosette formation (*),Emperipolesis (หัวลูกศรดำ)

Fig_1-A-300.jpg  Fig_1-B-300.jpg  Fig_1-C-300.jpg

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